• Users Online: 181
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Contacts Login 
COMMENTARY
Year : 2013  |  Volume : 5  |  Issue : 5  |  Page : 247-253

Novel oral anticoagulants: A new era in anti-thrombotic therapy


Hemostasis & Thrombosis Unit, Department of Hematology, Imperial College Healthcare NHS Trust Hospitals, London, UK

Correspondence Address:
Abdul Shlebak
Hemostasis & Thrombosis Unit, Department of Hematology, Imperial College Healthcare NHS Trust Hospitals, London
UK
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-489X.210553

Rights and Permissions

For over half-a-century vitamin K antagonists (VKAs) served our patients well as effective anticoagulants, several novel oral anticoagulants (NOACs) have emerged and are now available as a suitable alternative for stroke prevention, venous thromboembolism prevention and treatment and to reduce vascular events in acute coronary syndrome. Compared to VKAs, the novel agents have several advantages including an improved efficacy/safety ratio, a faster onset of action, shorter plasma half-life, few drug or food interactions, and no requirement for regular monitoring. Although very promising in many regards their proper use will require new approaches in many daily aspects with dose adjustments may be required for patients with severe renal impairment or in the setting of drug interactions. The lack of specific antidote makes reversing their effect during bleeding or for emergency surgery particularly a major challenge. This article provides a focused overview on their current status.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed628    
    Printed51    
    Emailed0    
    PDF Downloaded95    
    Comments [Add]    
    Cited by others 1    

Recommend this journal