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ORIGINAL ARTICLE
Year : 2018  |  Volume : 10  |  Issue : 5  |  Page : 169-173

Hesperidin inhibits angiogenesis, induces apoptosis, and suppresses laryngeal cancer cell metastasis


1 Department of Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
2 Department of Otolaryngology, Faculty of Medicine, Banha University, Banha, Egypt

Correspondence Address:
Dr. Randa Samir Hana
Department of Biochemistry, Faculty of Medicine, Assiut University, Assiut
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmbs.ijmbs_21_18

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Introduction: Laryngeal carcinoma is the most common malignant head-and-neck tumor. Due to the low survival rate and the inadequate response to chemotherapy, effective therapy remains a challenge. Objectives: Therefore, the identification of new therapeutic options that preserve the larynx is needed. Hesperidin (Hsp) is a nontoxic plant flavanone that has proven effective against cancer. Materials and Methods: Hence, the current in vivo and in vitro study was conducted to determine whether Hsp might suppress metastasis of cancer larynx. Results: In an in vivo mouse metastasis model, Hsp suppressed metastasis of human Hep2 laryngeal cancer cells to the livers and lungs. In vitro assays, Hsp significantly inhibited angiopoietin 1 secretion (an angiogenic promotor) and increased annexin-V (an apoptotic indicator) in Hep2 cell culture at relatively low levels (10 μM). Conclusions: These studies suggest that Hsp deserves further investigation as a possible treatment option for laryngeal cancer.


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