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Year : 2018  |  Volume : 10  |  Issue : 3  |  Page : 83-87

Anti-Hepatitis B Antibody status in children with coeliac disease

1 Department of Paediatric Gastroenterology, Hepatology and Nutrition, Tripoli Medical Centre; Department of Paediatric, Faculty of Medicine, University of Tripoli, Tripoli, Libya
2 Department of Paediatric Gastroenterology, Hepatology and Nutrition, Tripoli Medical Centre, Tripoli, Libya

Correspondence Address:
Prof. Fauzi Abdalla Sagher
Department of Pediatric Gastroenterology, Hepatology and Nutrition, Tripoli Medical Centre, Tripoli
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmbs.ijmbs_25_18

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Objective: This study aimed to compare the antibodies response to hepatitis B virus (HBV) vaccine between Libyan children with coeliac disease (CD) and healthy control. Subjects and Methods: A total of 66 children with CD on a gluten-free diet (GFD) and 31 randomly allocated healthy children who received HBV vaccination according to the standard immunization schedule were included. Hepatitis B virus surface antigen (HBsAg) and the production of specific anti-HBs antibodies were evaluated in all patients and control participants using standard techniques. Patients with <10 IU/L anti-HBs antibodies were considered nonresponses to the vaccination. Results: None of the participants were HBsAg reactive. Forty-one of the 66 patients (62%) were female, and 25 (37.8%) were male. The mean age of the CD patients was 8.2 years (range, 22 months-15 years). Anti-HBs titers were positive in 40 (60.6%) patients and negative in 26 (39.3%) patients, whereas they were positive in 19 (61.2%) of the children in the control group and negative in 12 (38.7%).There was no significant difference in response to vaccine between the two groups (P = 0.83), the study revealed a statistically significant relation between negative anti-HBs titers and duration from the last dose of HBV vaccine (P = 0.004). Conclusion: In the present study, the response rate in Libyan children with CD on GFD was not different from healthy control. However, not all children need booster dose; only nonresponders need an intradermal test-booster dose to reassess the state of their memory cell before considering revaccination.

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