• Users Online: 562
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Contacts Login 
ARTICLE
Year : 2010  |  Volume : 2  |  Issue : 3  |  Page : 118-124

In vivo schizonticidal activity of ethanolic leaf extract of gongronema latifolium on plasmodium berghei berghei in mice


1 Department of Pharmacology & Toxicology, National Institute for Pharmaceutical Research and Development, P.M.B. 21, Abuja, Nigeria
2 Department of Pharmacology & Therapeutics, Faculty of Clinical Medicine, Ebonyi State University, Abakiliki, Nigeria
3 Department of Pharmacology & Therapeutics, College of Medicine, University of , Enugu Campus, Enugu, Nigeria

Correspondence Address:
U A Osunkwo
Department of Pharmacology & Toxicology, National Institute for Pharmaceutical Research and Development, P.M.B. 21, Abuja
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-489X.210981

Rights and Permissions

In vivo schizonticidal activity of ethanolic leaf extract of Gongronema latifolium on blood-borne chloroquine- sensitive Plasmodium berghei berghei in mice was determined so as to scientifically justify the traditional use of the plant in south eastern Nigeria (tropical rain forest region) for local management of malaria fevers. The ethanolic leaf extract of Gongronema latifolium (200 - 800mg/kg) was administered orally to mice during early and established Plasmodium berghei berghei infections and its repository action in blood was also determined. The leaf extract at these doses caused 71-81% inhibition of parasitemia in the suppressive test, 59-73% parasitemia inhibition in the repository test and a mean survival time of 25-29 days in the curative test. These results show significant (P<0.05) antiplasmodial activity in the four-day suppressive test and in the curative test. These findings support the traditional use of the leaf extract of Gongronema latifolium for local treatment of malaria.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed389    
    Printed46    
    Emailed0    
    PDF Downloaded70    
    Comments [Add]    
    Cited by others 3    

Recommend this journal